For Cheo Martínez, embittering the lives of others has become a daily practice, since he seems to enjoy the role of undesirable. His neighbors, tired of the difficult coexistence, decide to use a desperate strategy: hire a woman who makes him fall in love and convinces him to leave the building. But they don't hire just anyone. Carolina Rico, a bold and beautiful prostitute, accepts the job to escape from an evil mobster. However, the neighbors' plan falls apart because Cheo and Carolina fall in love.

Em Cali durante os anos 60 e 70, dois irmãos fazem malabarismos com a família, o romance e a busca conjunta de uma ambição ardente: dominar a indústria farmacêutica da Colômbia.